A surgical instrument includes a shaft assembly, an end effector, and a staple cartridge. The end effector includes a first jaw and a second jaw. The first jaw includes an anvil that is configured to form a plurality of staples pressed against the anvil. The first and second jaws are configured to transition between an open configuration and a closed configuration. The staple cartridge is received within the second jaw. The staple cartridge includes a deck and a plurality of staples. The deck has a plurality of staple openings. The staples are positioned within respective staple openings. At least one of the staple openings obliquely crosses a centerline of the end effector.
