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Nrp3 inhibitors sulfuryl fluoride and sulfuryl amide
专利权人:
INFLAZOME LIMITED
发明人:
CARRILLO ARREGUI, JOKIN,STRUTT, IAN,ONIONS, STUART,ALANINE, THOMAS,SHANNON, JONATHAN,ST-GALLAY, STEPHEN,THOM, STEPHEN,MACLEOD, ANGUS,MILLER, DAVID,COOPER, MATTHEW
申请号:
ARP180102334
公开号:
AR112685A1
申请日:
2018.08.15
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
1. Claim 1: a formula compound (1),Q is selected from O or s; W, x, y and Z are independent n, O, s, NH or CH respectively, of which at least one w, x, y and Z is n or NH; R1 is a unit price group, including at least one nitrogen atom, wherein - R1 - contains 1 to 7 different hydrogen or halogen atoms, or R1 is a divergent group, including Subtract a nitrogen atom, where - R1 - contains 1 to 7 different hydrogen or halogen atoms, and - R1 - is directly connected to 2W, X and or adjacent Z; R 2 is a cycle group located at position a, and can be replaced in other ways at position a; m is 0, 1, 2 or 3;Each cubic meter is a separate halo.-NH832222,-8323,-SH, or saturated or unsaturated hydrogen carbide group, wherein the hydrogen carbide group can be linear or branched, or can be or include cyclic group, in which case, the hydrogen carbide group can be replaced, in which case, the hydrogen carbide group can optionally include one or more heteroatoms, Or s in its carbon structure, any R 3m3 and any adjacent W, X and Z can form a saturated or unsaturated cyclic a-cycle group composed of 3 to 12 members as a whole, and the cyclic a-cycle group combined in cyclic a can be replaced.Reivindicación 1: Un compuesto de fórmula (1), en donde: Q se selecciona de O ó S; cada uno de W, X, Y y Z es independientemente N, O, S, NH o CH, en donde al menos uno de W, X, Y y Z es N o NH; R¹ es un grupo monovalente que comprende al menos un átomo de nitrógeno, en donde -R¹- contiene de 1 a 7 átomos diferentes de hidrógeno o halógeno, o R¹ es un grupo divalente que comprende al menos un átomo de nitrógeno, en donde -R¹- contiene de 1 a 7 átomos diferentes de hidrógeno o halógeno, y en donde -R¹- se une directamente a dos W, X, Y o Z adyacentes; R² es un grupo cíclico sustituido en la posición a, en donde R² puede estar opcionalmente sustituido de forma adicional; m es 0, 1, 2 ó 3; cada R³ es independientemente un halo, -OH, -NO₂, -NH₂, -N₃, -SH, o un grupo hidrocarbilo saturado o insaturado,
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