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POCHODNE SUROWICZEGO AMYLOIDU P ORAZ ICH WYTWARZANIE I ZASTOSOWANIE
专利权人:
Promedior Inc.
发明人:
WILLETT, W. SCOTT,CAIMI, RICHARD J.
申请号:
PL10784210
公开号:
PL2438083T3
申请日:
2010.06.04
申请国别(地区):
PL
年份:
2016
代理人:
摘要:
One aspect of the present invention relates to the surprising discovery that modification of a glycan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding sample of wild-type SAP isolated from human serum. The disclosure provides both variant human SAP polypeptides and methods for making the same. In particular, the present invention provides methods and compositions for in vitro and in vivo addition, deletion, or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, having a desired glycosylation pattern.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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