FORME CRISTALLISÉE I DU DIMALÉATE INHIBITEUR DE TYROSINE KINASE ET SES MÉTHODES DE PRÉPARATION

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专利权人:

JIANGSU HENGRUI MEDICINE CO. LTD.

发明人:

SUN, PIAOYANG,WU, GUAILI,YUAN, BO,CHEN, YONGJIANG

申请号：

EP13817593

公开号：

EP2873664A4

申请日:

2013.06.04

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

Provided are crystalline Form I of (R,E)-N-(4-(3-chloro-4-(pyridin-2-yl -methoxy)-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl)-3-(1-methylpyrr olidin-2-yl) propenamide dimaleate (called SHR1258 dimaleate for short), preparation methods thereof and pharmaceutical composition containing the same. Said crystalline Form I of SHR1258 dimaleate has good crystal stability and chemical stability, and can be used in preparation of medicaments for treating diseases relevant to EGFR receptor tyrosine kinase or HER-2 receptor tyrosine kinase.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/