A camera hand-piece for medical use includes a lighting system, an optical window, a fixed part in turn having an optical system for acquiring images through an optical window, an image sensor, electronic circuits for image processing, and optionally a prism. The hand-piece has an external part, which is mobile with respect to the internal fixed part, and rotatably commutable between at least two different working positions having different optical or lighting features, which are freely selectable by an operator. In one embodiment, the lighting system for lighting the framed field is positioned in the internal fixed part of the camera hand-piece, and the mobile distal part, non comprising electronic parts, can be sterilized in an autoclave.