ANTI-GLYPICAN-3 ANTIBODY HAVING IMPROVED KINETICS IN PLASMA

• 收藏
• 分享

专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

TOMOYUKI IGAWA,TAICHI KURAMOCHI,HIROTAKE SHIRAIWA,HIROYUKI TSUNODA,TATSUHIKO TACHIBANA,TAKAHIRO ISHIGURO

申请号：

HK10111189.6

公开号：

HK1144702B

申请日:

2010.12.01

申请国别(地区):

HK

年份:

2013

代理人:

摘要：

A method of modulating the plasma half-life of anti-glypican 3 antibody, a pharmaceutical composition comprising as an effective component the anti-glypican 3 antibody that has a plasma half-life that has been modulated, a method of preparing the anti-glypican 3 antibody and a pharmaceutical composition comprising the anti-glypican 3 antibody as an effective component are provided. Disclosed is a method of modulating the plasma half-life of anti-glypican 3 antibody by modifying an amino acid residue that is exposed on the surface of the anti-glypican 3 antibody and anti-glypican 3 antibody that has a plasma half-life that has been modulated by amino acid residue modification, a pharmaceutical composition comprising as an effective component the anti-glypican 3 antibody, and a method of preparing the anti-glypican 3 antibody and producing a pharmaceutical composition comprising the anti-glypican 3 antibody as an effective component.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/