METHODS FOR REDUCING REMNANT CHOLESTEROL AND OTHER LIPOPROTEIN FRACTIONS BY ADMINISTERING AN INHIBITOR OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN-9 (PCSK9)
SWERGOLD, GARY,思沃格德 盖瑞,思沃格德 蓋瑞,SASIELA, WILLIAM J.,塞席拉 威廉,塞席拉 威廉,PORDY, ROBERT C.,波迪 罗伯特,波迪 羅伯特
申请号:
TW103118525
公开号:
TW201505654A
申请日:
2014.05.28
申请国别(地区):
TW
年份:
2015
代理人:
摘要:
The present invention provides methods for reducing various lipoprotein fractions in the serum of patients. The methods of the invention include reducing serum remnant cholesterol, and/or the serum concentration of one or more LDL-C subfractions in a patient. The methods of the present invention comprise selecting a patient who exhibits elevated serum lipoproteins, and administering to the patient a pharmaceutical composition comprising a PCSK9 inhibitor. In certain embodiments, the PCSK9 inhibitor is an anti-PCSK9 antibody such as the exemplary antibody referred to herein as mAb316P.本發明提供了降低患者血清中各種脂蛋白組分的方法。本發明之方法包括降低患者的血清殘餘膽固醇和/或一種或多種LDL-C亞組分的血清濃度。本發明之方法包括選擇顯示出血清脂蛋白水平升高的患者,並給該患者施用一種含PCSK9抑制劑的醫藥組合物。在某些實施例中,所述PCSK9抑制劑是一種抗PCSK9抗體,例如本文稱為mAb316P的示範性抗體。