PROBLEM TO BE SOLVED: To provide a GM-CSF production inhibitor having an excellent effect for preventing and improving a rough surface symptom, an inflammation and an allergy symptom caused by a variety of skin diseases such as atopic dermatitis, contact dermatitis or the like, and in addition, the rough surface and a sensitive skin of a healthy person, to provide an atopic dermatitis curing agent of the atopic dermatitis or the like containing the GM-CSF production inhibitor as an effective component, food and cosmetics, and to provide a skin care composition for preventing and improving the rough surface.SOLUTION: There are provided the GM-CSF production inhibitor with an extract of euphorbiaceae alchornea as an effective component, the atopic dermatitis curing agent blended with one or more kinds of the GM-CSF production inhibitors, the cosmetics, the food and the skin surgery agent.COPYRIGHT: (C)2012,JPO&INPIT【課題】本発明の課題は、アトピー性皮膚炎、接触皮膚炎等、種々の皮膚疾患による肌荒れ症状や炎症、アレルギー症状の他、健常人の肌荒れ、敏感肌に対する予防、及び改善に優れた効果を有するGM-CSF産生抑制剤及びそれを有効成分として含むアトピー性皮膚炎等のアトピー性皮膚炎治療剤、食品、化粧品、肌荒れ防止・改善用皮膚外用剤組成物の提供。【解決の手段】イポルル(Euphorbiaceae Alchornea)の抽出物を有効成分とするGM-CSF産生抑制剤及び前記GM-CSF産生抑制剤の一種以上を配合したアトピー性皮膚炎治療剤、化粧料、食品及び皮膚外用剤の提供。
