The compounds of formula (I)(see formula I)whereinX represents a bond or NH-CH(C=O)-(CH2)3+n-NH-R5,n represents 0, 1 or 2,R1, R4 and R5 - independently from each other - represent hydrogen, possiblysubstitutedC1-C6-alkyl, amidino or tetra-C1-C6-alkylamidinium,R2 represents hydrogen or possibly substituted C1-C5-alkylor R1 and R2 together with the residue to which they are bound represent a 5-to 7-membered,saturated ring,R3 represents C1-C12-alkoxy, C1-C12-alkylamino, possibly substituted aryl-C1-C5-alkylamino,possibly substituted heteroaryl-C1-C6-alkylamino, possibly substituted aryl-C1--C6-alkoxyor possibly substituted heteroaryl-C1-C6-alkoxy, andR6 represents hydrogen or, when n is 1, also amino or together with R1 and theresidue towhich R6 and R1 are bound a 5- to 7-membered, saturated ring, as well as theirphysiologically acceptable salts are new. They can be manufactured accordingtocommon methods and processed to topically applicable compositions that areappropriatefor treating mimic and age-related wrinkles in human skin.
