FORSBLOM, RICKARD,PAULSEN, KIM,ROTTICCI, DIDIER,SANTANGELO, ELLEN,WALDMAN, MAGNUS
申请号：
EP09825066
公开号：
EP2367826A4
申请日:
2009.11.05
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The present invention relates to novel compounds of formula I and therapeutically acceptable salts thereof, their pharmaceutical compositions, processes for making them and their use as therapeutic methods for treatment and/or prevention of various diseases. In particular the invention relates to compounds, which inhibit the Aβ40 and Aβ42 production, increase the Aβ37 and Aβ38 production and maintain the Notch signaling and will be used for treatment and/or prevention of Aβ-related pathologies such as Alzheimers disease, Downs syndrome and β-amyloid angiopathy, such as but not limited to cerebral amyloid angiopathy, hereditary cerebral hemorrhage, disorders associated with cognitive impairment, such as but not limited to MCI ("mild cognitive impairment"), Alzheimers disease, memory loss, attention deficit symptoms associated with Alzheimers disease, neurodegeneration associated with diseases such as Alzheimers disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinsons disease, progressive supranuclear palsy or cortical basal degeneration.La présente invention concerne des composés inédits de formule I et leurs sels thérapeutiquement acceptables, des compositions pharmaceutiques en contenant, leurs procédés de fabrication et leur utilisation dans le cadre de méthodes thérapeutiques destinées au traitement et/ou à la prévention de diverses maladies. Linvention concerne, en particulier, des composés inhibant la production dAβ40 et dAβ42, entraînant une augmentation de la production dAβ37 et dAβ38 et assurant le maintien de la signalisation Notch. Ces composés seront utilisés pour le traitement et/ou la prévention de pathologies associées à la protéine β-amyloïde, comme la maladie dAlzheimer, la trisomie 21 et langiopathie amyloïde, par exemple mais la liste nest pas limitative, langiopathie amyloïde cérébrale, lhémorragie cérébrale héréditaire, les troubles associés au d
