Aya Jakobovits,Soudabeh Etessami,Pia M. Challita-Eid,Juan J. Perez-Villar,Karen J. Morrison,Xiao-Chi Jia,Mary Faris,Jean Gudas,Arthur B. Raitano
申请号：
US14604658
公开号：
US09617346B2
申请日:
2015.01.23
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response； antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
