Michael J. Cope,Paul Mansky,Futian Liu,Han-Ting Chang,Dominique Charmot,Eric Connor,Kalpesh Biyani,Mingjun Liu,Tony Kwok-Kong Mong,Yan Chen
申请号：
US15869930
公开号：
US20180133244A1
申请日:
2018.01.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
