Surgical instruments with position-dependent actuator cooperation and impedance are described herein. In general, movement of one actuator can cause proportional movement of another actuator depending upon the positions of each actuator. In one embodiment, a surgical instrument can include a distal end effector and a proximal actuator portion. First and second actuators coupled to the proximal actuator portion can each be configured to move between a first position and a second position. Further, the first actuator and the second actuator can be configured such that, when the first actuator and the second actuator are in the first position, moving the second actuator to the second position causes the first actuator to move to the second position, and when the first actuator is in the second position, the second actuator can be moved from the first position to the second position independent of the first actuator.
