David Ho,Yaoxing Huang,Craig Pace,Ruijiang Song,Qing Fang
申请号：
US13294652
公开号：
US20120121597A1
申请日:
2011.11.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed herein are fusion antibodies created to provide both an antigen-binding site that targets the CD4 receptor and an antigen-binding site that targets the HIV envelope. The fusion antibodies disclosed herein provide improved potency and breadth against HIV as compared to monospecific antibodies, and additionally provide high barrier against viral resistance. Also disclosed are pharmaceutical formulations and therapeutic methods utilizing such fusion proteins.
