Shawn P. Walsh,Alexander Pasternak,Reynalda K. DeJesus,Haifeng Tang,Barbara Pio,Aurash Shahripour,Kevin M. Belyk,Harry R. Chobanian,Yan Guo,Jessica L. Frie,Zhi-Cai Shi,Helen Chen,Timothy A. Blizzard,B
申请号：
US14353804
公开号：
US09139585B2
申请日:
2012.10.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention relates to compounds of Formula I-VI having the following general structure:and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
