Apparatus and method for extracting a biopsy sample and injecting a therapeutic material through a same cannula are presented. The apparatus is particularly adapted to sampling and treating cancellous bone tissue. A cannula, which may be configured to undergo a particular plastic transformation during use, may be used with a stylet and/or biopsy needle and with a material source operable to supply a therapeutic material such as a bone filler or cement through the stylus under pressure.
