METHOD OF USING NEFERINE FOR INDUCING CELL DEATH IN APOPTOSIS RESISTANT CELLS THROUGH ACTIVATION OF RYANODINE RECEPTOR AND FOR TREATING APOPTOSIS RESISTANT CANCER
WONG, Kam Wai,LAW, Yuen Kwan,LIU, Liang,YAO, Xiao Jun
申请号：
AU2014101470
公开号：
AU2014101470A4
申请日:
2014.12.17
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2014101470A420150319.pdf#####Abstract The present invention provides a ryanodine activator for use in inducing cell death in apoptosis-resistant cells or cancer / tissues having the apoptosis-resistant cells. In particular, the present invention uses neferine as the ryanodine activator for inducing cell death in the apoptosis-resistant cells of cancer in order to treat said cancer. The present invention also provides a method of screening potential drug candidate for treatment of apoptosis-resistant cancer comprising creating cell or animal models with specific knock out of gene expressing ryanodine receptor in order to determine whether said candidate is a ryanodine receptor activator which is capable of inducing cell death selectively in apoptosis-resistant cells. 204w.w unA uo Juno,-) 51,
