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Thiazolyl or thiadiazolyl substituted pyridyl compounds useful as kinase inhibitors
- 专利权人:
- Bristol-Myers Squibb Company
- 发明人:
- PAIDI, Venkatram Reddy,KUMAR, Sreekantha Ratna,NAIR, Satheesh Kesavan,BANERJEE, Abhisek,SISTLA, Ramesh,PITTS, William J.,HYNES, John
- 申请号：
- ES13700833
- 公开号：
- ES2575604T3
- 申请日:
- 2013.01.11
- 申请国别(地区):
- ES
- 年份:
- 2016
- 代理人:
- 摘要：
- A compound having the following formula: ** Formula ** or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein X is N or C-R7； R is R1, halogen, cyano, nitro, -O-R1, -C (>； = O) -R1, -C (>； = O) O- R1, -C (>； = O) NR11-R1, -S ( >； = O) 2- R1, -NR11C (-O) -R1, -NR11C (>； = O) NR11-R1, -NR11C (>； = O) O-R1, -NR11S (>； = O) 2-R1, or -NR11-R1； R1 is C1-6 alkyl substituted with 0-4 R1a, halo C1-6 alkyl, C2-6 alkenyl substituted with 0-3 R1a, C2-6 alkynyl substituted with 0-3 R1a, C3-10 cycloalkyl substituted with 0-3 R1a , C6-10 aryl substituted with 0-3 R1a, a 5-10 membered heterocycle containing 1-4 heteroatoms selected from N, O and S, substituted with 0-3 R1a, a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O and S, substituted with 0-3 R1a； R1a is hydrogen,>； = O, F, Cl, Br, OCF3, CN, NO2, - (CH2) rORb, - (CH2) rSRb, - (CH2) rC (O) Rb, - (CH2) rC (O) ORb, - (CH2) rOC (O) Rb, - (CH2) rNR11R11, - (CH2) rC (O) NR11R11, - (CH2) rNRbC (O) Rc, - (CH2) rNRbC (O) ORc, -NRbC (O) NR11R11, -S (O) pNR11R11, -NRbS (O) pRc, -S (O) Rc, -S (O) 2Rc, C1-6 alkyl substituted with 0-2 Ra, C1-6 haloalkyl, - (CH2) 3-14 member r-carbocycle substituted with 0-3 Ra or - (CH2) 5-7 member r-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-3 Ra； R2 is C6-10 aryl substituted with 0-4 R2a, a 5-10 membered heterocycle containing 1-4 heteroatoms selected from N, O and S, substituted with 0-4 R2a, a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O and S, substituted with 0-4 R2a； R2a at each occurrence is independently selected from hydrogen,>； = O, halo, OCF3, CN, NO2, - (CH2) rORb, - (CH2) rSRb, - (CH2) rC (O) Rb, - (CH2) rC ( O) ORb, - (CH2) rOC (O) Rb, - (CH2) rNR11R11, - (CH2) rC (O) NR11R11, - (CH2) rNRbC (O) Rc, - (CH2) rNRbC (O) ORc, -NRbC (O) NR11R11, -S (O) pNR11R11, -NRbS (O) pRc, -S (O) Rc, -S (O) 2Rc, C1-6 alkyl substituted with 0-2 Ra, C1-6 haloalkyl
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
