A medical tube holder, for securing a tube relative to a patient, comprises an elongate patient engaging portion for passing around at least a part of a neck and mouth region of a patient a tube holding portion, connected to the patient engaging portion, for passing around at least a part of a medical tube a tube-holding-portion securing arrangement for securing the tube holding portion around at least a part of the medical tube so that the medical tube can be securely positioned relative to the patient and a patient-engaging-portion securing arrangement for securing the patient engaging portion around the patients neck and mouth region to secure the medical tube holder to the patient. The patient-engaging-portion securing arrangement has a tightening arrangement to facilitate tightening of the patient engaging portion around the patients neck and mouth region, and a locking arrangement that prevents loosening of the patient engaging portion while allowing further tightening.