The invention relates to a copper contraceptive intrauterine system (IUS) with a flexible frame, which system is further capable of releasing a selective progesterone receptor modulator (SPRM), such as ulipristal acetate, for reducing or preventing bleeding side effects.本發明係關於一種具有可撓性框架之銅避孕子宮內系統(IUS),該系統進一步能夠釋放選擇性孕酮受體調節劑(SPRM),諸如醋酸烏利司他(ulipristal acetate),以減少或阻止出血副作用。