The present invention relates to a process for preparing a vesicle composition having a continuous phase constituted of an aqueous phase, including: melting an oil phase at a temperature of equal to or higher than a melting point of the oil phase, the oil phase containing following components (A) to (D): component (A) straight chain fatty acid having 14 to 24 carbon atoms component (B) branched fatty acid having 14 to 24 carbon atoms and having a certain structure component (C) tertiary amine compound and component (D) organic acid having 1 to 8 carbon atom(s), mass ratio of the component (A) and the component (B) being: (A)/(B)=70/30 to 40/60, and adding the melted oil phase to the aqueous phase while mixing thereof.
