Shanghai Pulmonary Hospital; Tongji University School of Medicine
发明人:
Huiping Li,Shanmei Wang
申请号：
US13957923
公开号：
US09228010B2
申请日:
2013.08.02
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to pharmaceutical and medical technologies, and more particularly to novel nanobodies against pulmonary surfactant protein A (SP-A) and their preparation methods. The nanobodies of the present invention comprises an amino acid sequence having certain formula. The present invention also relates to nucleic acid sequences encoding the nanobodies, their preparation method and their applications. Immunohistochemistry and in vivo imaging show that the nanobodies of the present inventions have high lung-targeting specificity.
