SHAWN DEFREES,DAVID A. ZOPF,CARYN BOWE,HENRIK CLAUSEN
申请号：
IN1624/KOLNP/2006
公开号：
IN256090B
申请日:
2006.06.13
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
The present invention provides conjugates between Granuloeyte Colony Stimulating Factor and PEG moieties. The conjugates and linked via an intact glycosyI linking group that is interposed between and covalentiy attached to the peptide and the modifying group. The conjugates and formed form both glycosylated and ungiycosyiated peptides by the action of a glycosyitransferase. The glycosyltransferase ligates and modified sugar moiety onto either an amino acid or glycosyl residue on the peptide, Also provided are pharmaceutical formulations including the conjugates, Methods for preparing the conjugates are also within the scope of the invention.
