vaccine, nucleic acid molecule, and method for preventing or treating cancer

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

David Weiner,JIAN YAN,Jewell Walters,Karuppiah Muthumani

申请号：

BR112015022367

公开号：

BR112015022367A2

申请日:

2014.03.14

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary "vaccine, nucleic acid molecule, and method for preventing or treating cancer" vaccine compositions comprising one or more nucleic acids encoding a or more amino acid sequences selected from the group consisting of tyrosinase (tyr) amino acid sequences, tyrosinase-related protein 1 (tyrp1), tyrosinase-related protein 2 (tyrp2), associated antigen protein 4 melanoma (magea4), growth hormone releasing hormone (ghrh), melan-a / mart-1 antigen, ny-eso-1 testicular cancer antigen, dog antigen Ny-eso-2 testicular cancer, preferably melanoma (prame) expressed antigen, wilms tumor 1 (wt1) and human telomerase reverse transcriptase (htert). The vaccine compositions may further comprise a nucleic acid encoding one or more other antigens including prostate specific antigen (psa). Further described are methods for preventing or treating cancer in a subject in need comprising administering to the subject a vaccine composition comprising a particular number of cancer antigens for treating or preventing a cancer. cancer in particular.1 / 1 resumo “vacina, molã‰cula de ã�cido nucleico, e, mã‰todo para prevenir ou tratar cã‚ncerâ€� sã£o descritas composiã§ãµes de vacina compreendendo um ou mais ã¡cidos nucleicos codificando uma ou mais sequãªncia(s) de aminoã¡cido selecionados do grupo que consiste de sequãªncias de aminoã¡cido da tirosinase (tyr), proteã­na 1 relacionada ã  tirosinase (tyrp1), proteã­na 2 relacionada ã  tirosinase (tyrp2), proteã­na 4 do antã­geno associado ao melanoma (magea4), hormã´nio de liberaã§ã£o de hormã´nio do crescimento (ghrh), antã­geno melan-a/mart-1, antã­geno de cã¢ncer de testã­culo ny-eso-1, antã­geno de cã¢ncer de testã­culo ny-eso-2, preferencialmente antã­geno expresso no melanoma (prame), tumor 1 de wilms (wt1) e transcriptase reversa de telomerase humana (htert). as composiã§ãµes da vacina podem compreender adicionalmente um ã¡cido nucleico codificando um ou mais outros antã­genos incluindo antã­geno especã­fico de prã³stata (psa

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/