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Nucleobase editors and uses thereof
专利权人:
President and Fellows of Harvard College
发明人:
申请号:
GB201808388
公开号:
GB201808388D0
申请日:
2016.10.22
申请国别(地区):
GB
年份:
2018
代理人:
摘要:
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing proteins or protein domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing proteins or domains, are provided.
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