#$%^&*AU2016204867B220170216.pdf#####NOVEL COMPOUNDS AND THERAPEUTIC USE THEREOF FOR PROTEIN KINASE INHIBITION Abstract Novel compound having the following formula: (I) wherein Y is N, 0, or S. Also disclosed are a pharmaceutical compositions comprising the same, methods for treating cancer using the same, and methods for the synthesis of the same. The novel compounds of the present invention are found to inhibit protein kinases, especially Checkpoint kinase Chkl/ Chk2. YR NN R3 N N 0 H (I)