A dose delivery device with a mouthpiece having an inlet, an outlet, and an air path extending between the inlet and the outlet. A dose chamber having an opening may hold a dose, e.g., for inhalation by a user. A disc element may be arranged to move between a closed position in which the disc element closes the opening of the dose chamber, and an open position in which the disc opens the dose chamber to permit introduction of the dose into the air path of the device. Movement of the disc element from the closed position to the open position may be in a direction away from the dose chamber (e.g., a puller may engage the disc element and pull the element away from the chamber) and may leave a substantial portion of the dose in the dose chamber.