[problem] provided a pharmaceutical composition for the treatment of solid malignant tumors, which involved one or more \u043a\u0438\u043d\u0430\u0437 of btk, JAK3 and ITK.[solution] the present invention studied compounds possessing \u0438\u043d\u0433\u0438\u0431\u0438\u0440\u0443\u044e\u0449\u0438\u043c btk effect, \u0438\u043d\u0433\u0438\u0431\u0438\u0440\u0443\u044e\u0449\u0438\u043c JAK3 effect and \u0438\u043d\u0433\u0438\u0431\u0438\u0440\u0443\u044e\u0449\u0438\u043c ITK effect and p \u043e\u0434\u0442\u0432\u0435\u0440\u0434\u0438\u043b\u0438 that specific connection \u043f\u0438\u0440\u0430\u0437\u0438\u043d\u043a\u0430\u0440\u0431\u043e\u043a\u0441\u0430\u043c\u0438\u0434\u0430 has \u0438\u043d\u0433\u0438\u0431\u0438\u0440\u0443\u044e\u0449\u0438\u043c btk effect, \u0438\u043d\u0433\u0438\u0431\u0438\u0440\u0443\u044e\u0449\u0438\u043c JAK3 effect and \u0438\u043d\u0433\u0438\u0431\u0438\u0440\u0443\u044e\u0449\u0438\u043c ITK effect and that the pharmacist tech compositionwhich contains the compound as an active ingredient, has therapeutic effect for the malignant tumor, which are of on or more \u043a\u0438\u043d\u0430\u0437 of btk, JAK3 and ITK, in another aspect of the malignant tumor, in which \u0441\u0432\u0435\u0440\u0445\u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0440\u043e\u0432\u0430\u043d\u0430 btk or activated, in another aspect of the \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442 \u0432\u0435\u043d\u043d\u0443\u044e tumor, which activated the signal in the cell \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0430,in another aspect of the other malignant tumor, in which JAK3 has \u043c\u0443\u0442\u0430\u043d\u0442\u043d\u043e\u0439 activated or activated, and still another aspect of the \u0437\u043b\u043e\u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u0443 yu tumor, in which ITK activated, thereby complying with the present invention.[Проблема] Предоставлена фармацевтическая композиция для лечения злокаче
