A spectral color and light therapy system is described which is useful in treating mood, anxiety, attention, substance, and/or behavioral disorders. The system utilizes one or more light source which emits visible colored light at a brilliance factor of at least about 2500 and at least one of four colors which are different from each other, said system providing (a) (i) a light source emitting blue light in the range of about 450 to about 475 nm and (ii) a source emitting green visible light in the range of about 495 nm to about 570 nm and (b) a light source emitting rose pink light in the range of about 635 nm to about 650 nm and a light source of peach light in the range of about 590 nm to about 630 nm. Also provided are methods of treating mood, anxiety, attention, substance, and/or behavioral disorders. Methods of treating and/or ameliorating the symptoms of autism spectrum disorders are described.