"Polynucleotide" refers to a polynucleotide encoded by a chemical antigen receptor (car) or a T cell receptor (TCR), including (I) a molecule polymerized to an antigen, (II) a common carrying domain and (III) an activating domain, in which the common carrying domain includes an outer domain, Transmembrane domain and intracellular domain It also refers to the components and methods of cancer treatment, such as leukemia, lymphoma or polio. Other aspects of the invention relate to mobile phones, including automobiles or TCRs and their use in T-cell therapy.Se refiere a un polinucleotido que codifica un receptor de antigeno quimerico (CAR) o un receptor de celulas T (TCR) que comprende (i) una molecula de union a antigeno, (ii) un dominio coestimulatorio, y (iii) un dominio activante, en donde el dominio coestimulatorio comprende un dominio extracelular, un dominio transmembrana y un dominio intracelular. Tambien se refiere a una composicion y metodo de tratamiento contra el cancer, como la leucemia, linfoma o mieloma. Otros aspectos de la invencion se refieren a celulas que comprenden el CAR o el TCR y su uso en una terapia de celulas T.
