POPOV, ALEXEY,ENLOW, ELIZABETH M.,CHEN, HONGMING,BOURASSA, JAMES
申请号：
CA2928969
公开号：
CA2928969A1
申请日:
2014.10.31
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.
