УОТТС Райан Дж. (US),ЮЙ Джой (US),ДЕННИС Марк (US),ФРЕСКГАРД Пер-Ола (CH),ТАМ Стефен (US)
申请号：
RU2012136137/15
公开号：
RU2012136137A
申请日:
2011.01.21
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A composition comprising a molecule binding to LRP8, and at least one active against CNS soedinenie.2. A composition according to claim 1, wherein the molecule binds to LRP8, conjugated to at least one active against CNS soedineniem.3. A composition according to claim 2, wherein said conjugation is carried out by a covalent bond between the molecule that binds to LRP8, and at least one active against CNS soedineniem.4. A composition according to claim 2, wherein said conjugation is carried out by linkera.5. A composition according to claim 1, wherein the molecule binds to LRP8, selected from LRP8 natural ligand, a fragment of a natural ligand LRP8, a modified form of the natural ligand LRP8 fragment and a modified form of the natural ligand LRP8.6. A composition according to claim 5, wherein said natural ligand is selected from LRP8 reelin and selenoproteins P.7. A composition according to claim 1, wherein the molecule binds to LRP8, represents antitelo.8. A composition according to claim 7, wherein said antibody is a multispecific antitelom.9. A composition according to claim 7, wherein said antibody is selected from monoclonal antibodies, human antibodies, humanized antibodies, chimeric antibodies, and antibody fragment that binds to LRP8.10. A composition according to claim 1, wherein the molecule binds to LRP8, does not compete with one or more natural ligands for binding to LRP8 LRP8.11. A composition according to claim 1, wherein the molecule binds to LRP8, competes with one or more natural ligands for binding to LRP8 LRP8.12. A composition according to claim 1, wherein said molecule binds to LRP8, binds to the extracellular domain LRP8.13. A composition according to claim 1,1. Композиция, содержащая молекулу, связывающуюся с LRP8, и по меньшей мере одно активное в отношении ЦНС соединение.2. Композиция по п.1, в которой молекула, связывающаяся с LRP8, конъюгирована по меньшей мере с одним активным в отношении ЦНС соединением.3. Композиция по п.2, в которой
