Jefferies, Wilfred,Basha, Genc,Omilusik, Kyla,Chavez-Steenbock, Ana
申请号：
AU2012367204
公开号：
AU2012367204A1
申请日:
2012.07.31
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Compositions for and methods of stimulating a M HC I mediated immune response comprising stimulating MHC I endolysosomal cross presentation in dendritic cells. Stimulation MHC I endolysosomal cross presentation may comprise over-expression CD74 in dendritic cells and/or targeting antigens to the MHC I endolysosomal cross presentation pathway. Fusion proteins comprising an antigen or fragment thereof and a CD74 endolysosomal targeting sequence are also provided.
