Compositions comprising a polymeric matrix made of a thermoplastic polymer and a photosensitizer incorporated in the polymeric matrix are provided. Also provided are processes of preparing the compositions, without using an organic solvent or a surfactant. Articles-of-manufacturing comprising the compositions, which can be self-disinfecting, and uses of the composition or articles-of-manufacturing comprising same for disinfecting bodily or inanimate substrates such as water are also provided.
