PROBLEM TO BE SOLVED: To provide a decontamination device capable of conducting sufficient decontamination in a short time, and capable of preventing generation of a dew condensation liquid regardless of kinds of a used decontamination agent, and an air cleaning system with the same.SOLUTION: A decontamination device has an air suction port 100a into which air of a cell preparation chamber 80 is sucked, a hydrogen peroxide gas generator 131 for releasing hydrogen peroxide gas to air sucked from the air suction part 100a, a diffusion fan 104 for conducting decontamination of the cell preparation chamber 80 by supplying air after release of the hydrogen peroxide gas to the cell preparation chamber 80 through a diffusion port 100b, path boxes 101, 102, and a fan 112 for path box for conducting decontamination in the path boxes 101, 102 by supplying air after release of the hydrogen peroxide gas into the article housing cabinet through ventilation ports 100d, 100e.SELECTED DRAWING: Figure 2【課題】短時間に十分な除染を行うことができるとともに、使用される除染剤の種類に関わらず結露液の発生を防止可能な除染装置及びそれを備える空気清浄システムを提供する。【解決手段】細胞調製室80の空気が吸い込まれる空気吸込口100aと、空気吸込口100aから吸い込まれた空気に対し、過酸化水素ガスを放出する過酸化水素ガス発生装置131と、過酸化水素ガスを放出した後の空気が拡散口100bを通じて細胞調製室80に給気されることで、細胞調製室80の除染を行う拡散ファン104と、パスボックス101,102と、過酸化水素ガスを放出した後の空気が通風口100d,100eを通じて前記物品収納庫の内部に給気されることで、パスボックス101,102の内部の除染を行うパスボックス用ファン112と、を備える。【選択図】図2