Golden Biotechnology Corporation;Wu-Che Wen;Chih-Ming Chen;Sheng-Yung Liu
发明人:
Liu, Sheng-Yung,Wen, Wu-Che,Chen, Chih-Ming
申请号：
AU2013239861
公开号：
AU2013239861A1
申请日:
2013.03.26
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention provides methods and compositions for treating arteriosclerotic vascular diseases by cyclohexenone compounds. In some embodiments, the compound in the methods inhibits PDGF-stimulated smooth muscle cell proliferation or migration. In some embodiments, the atherosclerosis is associated with coronary artery disease, aneurysm, arteriosclerosis, myocardial infarction, embolism, stroke, thrombosis, angina, vascular plaque inflammation, vascular plaque rupture, Kawasaki disease, calcification or inflammation. In some embodiments, the compound lowers low-density lipoprotein (LDL) cholesterol in the subject. In some embodiments, the compound maintains a normal low-density lipoprotein (LDL) cholesterol level in the subject.
