The present invention provides a kind of Peramivir hydrate crystal, the preparation method of the crystal, the application comprising the Pharmaceutical composition of the crystal and the crystal in the drug for preparing resisiting influenza virus, and the structural formula of Peramivir is as follows:本發明提供一種帕拉米韋水合物晶體,該晶體的製備方法,包含該晶體的藥用組合物以及該晶體在製備抗流感病毒的藥物中的應用,帕拉米韋的結構式如下: