The present invention refers to a non-shivering cryothermogenesis method for locally reducing adipose tissue of a subject's body, comprising:(a) applying at least one applicator of a cooling mean to the subject's skin；(b) applying at least one additional applicator of said cooling mean to local region wherein adipose tissue reduction is desired；(c) said applicator maintaining skin superficial temperature between 4°C and 12°C；(d) applying said applicators for a total period of time comprised between 20 and 60 min；
