WILL, DAVID WILLIAM,REID, GEORGE,CHARAPITSA, IRYNA,LEWIS, JOE DAVID
申请号：
CA3067086
公开号：
CA3067086A1
申请日:
2018.06.14
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relatesto a pharmaceutical composition comprising acompound of the formula Ias described belowor a tautomeror a pharmaceutically acceptable salt thereof； to the compound of the formula Ias described below or a tautomer or a phar- maceutically acceptable salt thereof for use as a medicament, especially for use in the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization, and to certain novel compoundsof the formula Ias described below or a tautomer or a pharmaceuti- cally acceptable salt thereof. Formula (I) wherein X1 is CR1 or N； X2 is CR2 or N； X3 is CR3 or N； X4 is CR4 or N； with the proviso that at most two of X1, X2, X3 and X4 are N； L1, L2 are a bond or a bivalent radical such as C1-C6-alkylene or C3-C8-cycloalkylene； A is 3-, 4-, 5-, 6-, 7- or 8-membered saturated, partially unsaturated or maximally unsaturated carbocyclic ring which may carry one or more substituents R9； or L2-A forms a group C1-C6-alkylene-OR13, C1-C6-alkylene-SR14 or C1-C6-alkylene-NR15R16； and R1, R2, R3, R4, R5, R6, R9, R13, R14, R15 and R16 are as defined in the claims and the description.
