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TRAITEMENT DU CANCER PAR DES ANTAGONISTES DES RECEPTEURS DOPAMINERGIQUES
专利权人:
MCMASTER UNIVERSITY
发明人:
BHATIA, MICKIE,SACHLOS, ELEFTHERIOS,RISUENO, RUTH MUNOZ
申请号:
CA2865819
公开号:
CA2865819A1
申请日:
2012.02.28
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and methods for identifying subjects likely to be responsive to therapy with DR receptor antagonists. Methods for identifying cancer stem cells and chemotherapeutic compounds that are DR receptor antagonists as also provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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