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methods for treating, improving or protecting (preventing) an individual or a patient, and for a dysfunction, disease, infection or condition, and, method for suppressing weight gain, or suppressing apepite, or stimulating or initiating weight loss
专利权人:
THE REGENTS OF THE UNIVERSITY OF CALEFORNIA
发明人:
H. KIRK HAMMOND,MEI HUA GAO
申请号:
BR112014020127
公开号:
BR112014020127A2
申请日:
2013.02.13
申请国别(地区):
BR
年份:
2020
代理人:
摘要:
use of a gene or nucleic acid encoding paracrine polypeptide, use of a vector comprising a nucleic acid sequence, and, vector in alternative embodiments, the invention provides methods for treating, improving or protecting (preventing) an individual or a patient against a disease, infection or condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a gene or nucleic acid encoding paracrine polypeptide functionally linked to a transcriptional regulatory sequence; or an expression vehicle, a vector, a recombinant virus, or equivalent, having contained in it a paracrine-encoding gene or nucleic acid, and the expression vehicle, vector, recombinant virus, or equivalent can express the encoding gene or nucleic acid of paracrine polypeptide in a cell or in vivo; and administering or releasing the gene or nucleic acid encoding a paracrine polypeptide functionally linked to a transcriptional regulatory sequence, or the vehicle of expression, vector, recombinant virus, or equivalent, to an individual or a patient in need of it, treating, improving or thus protecting (preventing) the individual or patient against the disease, infection or condition responsive to an increased level of paracrine polypeptide.uso de um gene ou ácido nucleico codificador de polipeptídeo parácrino, uso de um vetor compreendo uma sequência de ácido nucleico, e, vetor em modalidades alternativas, a invenção fornece métodos para tratar, melhorar ou proteger (prevenir) um indivíduo ou um paciente contra uma doença, uma infecção ou uma condição responsiva a um nível de polipeptídeo parácrino aumentado in vivo compreendendo: fornecer um gene ou ácido nucleico codificador de polipeptídeo parácrino funcionalmente ligado a uma sequência regulatória transcricional; ou um veículo de expressão, um vetor, um vírus recombinante, ou equivalente, tendo contido no mesmo um gene ou ácido nucleico parácrino-codificador, e o veículo de expressão, vetor, vírus recombinante, ou equ
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