A drug delivery device 1 with a resettable dose setting mechanism , the mechanism including a housing 40, a rotating sleeve 10 in rotatable engagement with respect to the housing 40, a driver 30 for driving a spindle of the drug delivery device having a first component 44 and a second component 46, the first and the second component being operatively coupled together, by rotationally coupling the second component 46 to the first component 44, and the spindle is operatively coupled to the driver 30. When a user sets a dose by rotating the rotating sleeve 10, both the first component 44 and the second component of the driver rotate together. When the user resets the dose setting mechanism, the first component 44 of the driver is rotationally decoupled from the second component 46 of the driver and the first component 44 can rotate back to an original position.