According to one aspect of the presently disclosed subject matter, there is provided a system for facilitating active protection of a target from a threat, the system comprising: €¢ one or more platforms configured for directing operation of the system; and €¢ one or more unmanned aerial vehicles (UAV's) configured to operate in the vicinity of the target, and to facilitate detection and/or neutralizing of the threat, wherein the platform is configured for autonomously detecting and providing instructions for neutralizing the threat, and wherein each of the unmanned aerial vehicles is configured for communicating (e.g., directly, without relying on any system external thereto and/or to the target) with the platform (e.g., the platform being configured to issue instructions to the UAV's).