The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Methionine Sulfoxide Reductase A (MSRA), in particular, by targeting natural antisense polynucleotides of Methionine Sulfoxide Reductase A (MSRA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of MSRA.本發明係關於反股(antisense)寡核苷酸,其特別藉由靶向甲硫胺亞磺酸(Methionine Sulfoxide)還原酶A(MSRA)之天然反股多核苷酸來調節甲硫胺亞磺酸還原酶A(MSRA)之表現及/或功能。本發明亦關於該等反股寡核苷酸之鑑別,及其在治療與MSRA表現有關之疾病及病症之用途。