The present invention relates to amylin analogues and to their use in the treatment or prevention of a variety of diseases, conditions or disorders, including obesity, excess food intake and associated metabolic diseases such as diabetes. The analogues have good physical and chemical stability, good solubility, and a long duration of action, and are well suited for use in the form of a liquid formulation.本發明係關於澱粉素類似物,及其在治療或預防各種疾病、病況或病症(包括肥胖症、過量食物攝取及相關代謝疾病,例如糖尿病)中之用途。該等類似物具有良好物理及化學穩定性、良好溶解性及長作用期間,且非常適合以液體調配物之形式使用。