LIU, QINGJIE,BATT, DOUGLAS G.,DELUCCA, GEORGE V.,SHI, QING,TEBBEN, ANDREW J.
申请号：
ES09793680
公开号：
ES2443948T3
申请日:
2009.12.17
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound according to formula (I): ** Formula ** or a salt thereof, in which the dotted lines are single or double bonds； A is halo, C3-10 carbocycle substituted with 0-3 B, mono or bicyclic C6-10 aryl, substituted with 0-3 B, a 5-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O and S , substituted with 0-3 B, a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O and S, substituted with 0-3 B； B is R1, halogen, cyano, nitro, -O-R1, -C (>； = O) -R1, -C (>； = O) O- R1, -C (>； = O) NR11-R1, -S ( >； = O) 2- R1, -NR11C (>； = O) - R1, -NR11C (>； = O) NR11- R1, -NR11C (>； = O) O- R1, -N (C (>； = O) O - R1) 2, -NR11S (>； = O) 2- R ', -N (S (>； = O) 2-R1) 2 or -NR11-R1； R1 is hydrogen, C1-6 alkyl substituted with 0-3 R1a, halo C1-6 alkyl, C2-6 alkenyl substituted with 0-3 R1a, C2-6 alkynyl substituted with 0-3 R1a, C3-10 cycloalkyl substituted with 0- 3 R1a, C6-10 aryl substituted with 0-3 R1a, a 5-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O and S, substituted with 0-3 R1a, a 5-10 membered heteroaryl which contains 1-4 heteroatoms selected from N, O and S, substituted with 0-3 R1a； R1a is hydrogen,>； = O, F, Cl, Br, OCF3, CF3, CHF2, CN, NO2, - (CH2) rORb, - (CH2) rSRb, - (CH2) rC (O) Rb, - (CH2) rC (O) ORb, - (CH2) rOC (O) Rb, - (CH2) rNR11R11, - (CH2) rC (O) NR11R11, - (CH2) rNRbC (O) Rc, - (CH2) rNRbC (O) ORc, -NRbC (O) NR11R11, -S (O) pNR11R11, -NRbS (O) pRc, -S (O) Rc, -S (O) 2Rc, C1-6 alkyl substituted with 0-2 Ra, C1 haloalkyl -6, - (CH2) 3-14 member r-carbocycle substituted with 0-1 Ra or - (CH2) 5-7 member r-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-1 Ra； one of D1 and D2 is D and the others is H or halo； D is -R2, halogen, - (C (R11) 2) r-R2, -O-R2, -C (>； = O) -R2, -C (>； = O) O-R2, -C (>； = O) NR11-R2, -S (>； = O) 2-R2, -S (>； = O) -R2, -NR11C (>； = O) -R2, -NR11C (>； = O) NR11-R2, -NR11C (>； =
