Ian Armitage,Eric L. Elliott,Marianne Langston,Steven P. Langston,Quentin J. McCubbin,Hiro Mizutani,Matthew Stirling,Lei Zhu
申请号：
US15713293
公开号：
US10745404B2
申请日:
2017.09.22
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides processes and synthetic intermediate (Ia) for the synthesis of 4-substituted ((1S, 2S, 4R)-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates. These sulfamate compounds are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.
