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NON-AQUEOUS LIQUID COMPOSITION
专利权人:
发明人:
Kazuhito Yamada,Arto Urtti,Mechthild Burmester
申请号:
US14375251
公开号:
US20150011518A1
申请日:
2013.01.30
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A drug-dissolved non-aqueous liquid composition containing a drug, dioleylphosphatidylcholine, tocopherol and an organic solvent, wherein the blend concentration ratio between the dioleylphosphatidylcholine and the tocopherol falls within the range of 75/25 to 25/75, the blend concentration of the dioleylphosphatidylcholine falls within the range of 15 to 85% (w/w), the blend concentration of the tocopherol falls within the range of 15 to 85% (w/w), and the phase of the non-aqueous liquid composition changes into a non-lamellar liquid crystal upon contact with water, a phosphate buffer, a body fluid, a lacrimal fluid or a vitreous fluid.
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