Loany Calvo Gonzalez;Agustin Bienvenido Lage Davila;Gisela Maria Gonzal;Ernesto Chico Veliz;Ariadna Cuevas Fiallo;Tania Crombet Ramos;Gryssell Rodriguez Martinez;Lisel Vina Rodriguez;Arama Albisa Novo
发明人:
Gryssell Rodriguez Martinez,Lisel Vina Rodriguez,Loany Calvo Gonzalez,Ariadna Cuevas Fiallo,Ernesto Chico Veliz,Agustin Bienvenido Lage Davila,Tania Crombet Ramos,Arama Albisa Novo,Gisela Maria Gonzal
申请号：
US13346831
公开号：
US20130039940A1
申请日:
2012.01.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A vaccine composition for therapeutic use thereof on cancer patients includes a chemical conjugate of human recombining Epidermic Growth Factor (hrEGF) and a combining protein P64k for performing a conjugation reaction which produces said chemical conjugate in a controlled and reproducible manner. The preferred conjugate surprisingly increases the immunogenic activity causing significant increases in the anti-EGF antibody titers in humans, and provides a vaccine preparation with more than one type of effective dose presentation which enables the immunization dose per patient to be increased, but without involving an increase in immunization frequency and/or the number of immunization sites.
