The invention provides, inter alia, immunogenic compositions that comprise (a)a first antigen, (b) at least first andsecond adjuvants, wherein the first adjuvant comprises microparticles andwherein the second adjuvant comprises an imidazoquinolinecompound, and (c) a pharmaceutically acceptable excipient, which compositionselicits an immune response when administeredto a vertebrate subject. The invention also provides methods of producingimmunogenic compositions and methods for using immunogeniccompositions (e.g., for treatment), among other benefits.
